On 13 March, INSS led a timely, regional security discussion with Dr. Mahsa Rouhi on Operation Epic Fury.
On 12 March, the Defense Threat Reduction Agency (DTRA) and the National Defense University (NDU) co-hosted the Framework for Biological Weapons Deterrence: Report Rollout event.
Strategic Assessment 2025: Evolving Great Power Competition at Mid-Decade explores the ongoing dramatic evolution of strategic competition among and between today's three Great Powers — the United States, China, and Russia.
Every week, Strategic Insights brings analyses of critical policy issues that affect U.S. national security interests — from disruptive technologies to cognitive warfare, and more.

Highlighted Articles

The K1000 ultra-long range endurance Unmanned Aircraft System (UAS) is launched from a government owned non-tactical vehicle during the Army’s first battalion-level All-Domain Home Station Training (HST) exercise Static Focus 3 at Yakima Training Center, Wash., March 6th, 2025. The Army’s first MDO HST exercise enabled live training of the MDEB’s family of systems used to conduct Reconnaissance, Surveillance, and Target Acquisition (RSTA) and non-kinetic effects execution. (U.S. Army photo by Staff Sgt. Brandon Rickert)

Irregular Warfare, Part One: Updating the Term and the Toolkit

Jocelyn Garcia and Dr. James Giordano

Irregular warfare (IW) is not a new phenomenon, although its contemporary character has been substantively reshaped by advancements in technology, and more specifically, by the developments in AI.

Artificial intelligence-powered training is a force-multiplier that can also scale to support more hours of training for more servicemembers. (Graphic provided by CAE)

Synthesized Command & Control: A new way human choices can guide AI warfighting

Elise Annett and James Giordano

As the U.S. military races to adapt to ever-larger amounts of increasingly advanced, and iteratively autonomous AI, how do humans stay in control?

Illuminated brain map with network pathways

Losing the Loop: A Model for Human Operational Involvement Part Two: A Proposed System Toward a Solution

Dr. Elise Annett and Dr. James Giordano

Last week’s “Losing the Loop: Iteratively Autonomous Artificial Intelligence and the Question of Human Operational Involvement” examined how increasing autonomy in agentic AI reshapes the structure, tempo, and locus of human decision-making in operational environments, particularly as these systems transition from analytic tools to increasingly directive and generative components of the human–machine team. Seen in sequence, the logic is cumulative. The first section demonstrates how autonomy can erode the integrity of the decision loop. The second makes that erosion visible, locating the specific points at which human judgment becomes constrained or displaced.

Futuristic War Strategy

Losing the Loop: Iteratively Autonomous Artificial Intelligence and the Question of Human Operational Involvement

Dr. Elise Annett and Dr. James Giordano

The U.S. Department of War is rapidly scaling the integration of artificial intelligence (AI) to the warfighter, streamlining routine tasks so operators can focus on what matters most. The successful launch of GenAI.MIL signals both momentum and institutional commitment to embedding AI across operational environments.

A laboratory technician wearing full protective gear works inside a biosafety cabinet in a high-containment lab. The worker handles glass equipment and samples while surrounded by petri dishes and scientific instruments. Signs on the cabinet reference “Pathogen Construct” and “Aerosol Stability,” and a “BSL-3 Access” warning is visible, indicating research involving potentially hazardous biological materials.

Breaking (Bad) Biotech — Revisiting the Biological and Toxin Weapons Convention

Dr. James Giordano

Dr. Giordano explores how advances in biotechnology, like gene editing and AI, allow adversaries to easily create novel, weaponizable biological agents that are difficult to detect and defend against. In an evolving operational environment, the nature of biological warfare has shifted.

Research & Analysis